I’ve been using EyeXMouse which seems to be based on gigertron’s work and have had a degree of success I’d like to share.
Hearthstone using EyeXMouse:
http://youtu.be/FYN-7EPbcvs?list=UUumqIFsH1ZTQw3wpHfQbaOg
Works great! Slow pace and large hotspots make for an enjoyable experience.
Osu! using EyeXmouse:
http://youtu.be/VH4yduiveEY?list=UUumqIFsH1ZTQw3wpHfQbaOg
This is a bit more difficult because of the faster pace and smaller targets. This demonstrates the limits in averaging delay and calibration.
At the end of the video I continue to use EyeXMouse control to close the process. You can see how difficult it is to hit such small targets. I am confident this can be improved with tuning and calibration.